I rely on my secondary, so I tend to go:
2 CBs who are elite speed and man coverage (i very rarely run zone)
2 backup CBs for subpackages. often one of my backup safeties is in here somewhere
4 safeties, with the best speed/coverage skills i can find
I tend to play a lot of man Cover 1 Man and Cover 2 Man, with a lot of blitzing, so I rely on my corners being able to man-up effectively, and my safeties being able to do both. Thus I'll often draft defensive backs high, sometimes multiple times in a draft and sometimes multiple years in a row.