I have a loose rule I use for those probably guys. Any injury that puts them below 60, I'll sit them out. If it's above 70 I feel good about still playing them. The 60-69 is the gray area where I need to make a judgement call. If I've got the depth, they can sit out for a week or two. If not I may need to play them. But I may adjust the fatigue setting for that group if I have to.
This has worked for me so far.